Coordinator:

Jesús R. Requena,

Universidade de

Santiago de Compostela

Contact Person:

CACHEIRO MARTINEZ, Martin (Mr)
Tel: +34-981-547050
Fax: +34-981-528019
Email: Contact

Organisation:

UNIVERSIDADE DE
SANTIAGO DE COMPOSTELA
Pazo de San Xerome

Praza do Obradoiro
Santiago de Compostela

SPAIN

Project description

Bovine Spongiform Encephalopathy (BSE) started, 20 years ago, a devastating health and food crisis throughout Europe. Classical BSE is now under control as a result of the meat and bone meal ban. However, tonsil analyses suggest that there may be an alarmingly high number of asymptomatic PrPSc positive cases. Transmission through blood transfusion is another important concern, as are recent atypical cases of BSE.

Only a profound understanding of the molecular biology of prions will enable us to control them. Thus, to understand why BSE-contaminated food causes vCJD, we need to understand how prions get into food, what happens with them in the gut, how they reach the brain, and how they initiate the chain reaction rapidly leading to death. We have formulated 7 key questions:
* How can we avoid a new BSE outbreak, or other possible future prion infection of livestock?
* Why did decontamination of meat and bone meal fail; is there an effective way to decontaminate feedstuffs, soil etc?
* What is the risk of humans being infected with each of the different prion strains known thus far?

* Which are the best strategies to implement feasible prion eradication programs?

* How can we develop a pre-clinical prion blood test?

* How can we identify human cases with potential secondary transmission?* What is the origin of atypical human CJD cases?